Table 3.
Univariate and multivariate analyses of factors associated with disease-free survival of advanced gastric cancer.
| Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|
| HR (95% CI) | p Value | Adjusted HR (95% CI) |
p Value | ||
| Age (>72 years) | 1.326 (0.803–2.190) | 0.270 | |||
| pTNM (III + IV) | 13.386 (6.031–29.708) | <0.001 | |||
| LVPI (Present) | 11.050 (4.001–30.521) | <0.001 | |||
| Tumor size (>55.0 mm) | 2.761 (1.627–4.687) | <0.001 | |||
| CD15 | Margin (>2473.3/mm2) * | 2.269 (1.149–4.484) | 0.018 | 1.539 (0.746–3.174) | 0.243 |
| Center (>536.1/mm2) * | 2.393 (1.287–4.448) | 0.006 | 1.106 (0.597–2.050) | 0.749 | |
| cN2 | Margin (>949.3/mm2) * | 1.576 (0.800–3.106) | 0.188 | 1.066 (0.521–2.181) | 0.860 |
| Center (>954.6/mm2) * | 3.241 (1.888–5.566) | <0.001 | 2.614 (1.436–4.671) | 0.001 | |
| TSR (>40%) * | 10.768 (4.877–23.775) | <0.001 | 3.976 (1.643–9.620) | 0.002 | |
HR, hazard ratio; CI, confidence interval; LVPI, lymphovascular and perineural invasion; cN2, calculated tumor-associated neutrophils for pro-tumor function; TSR, tumor—stromal ratio. * Adjusted for age, pTNM, lymphovascular and perineural invasion, and tumor size.