FIG. 1.

A comparison of the nucleotide sequences of sulfonamide-resistant and -susceptible isolates of S. pneumoniae to the R6 sequence described by Lopez et al. (14). Only a section of the deduced sequence, containing the mutations observed, is shown above. The complete sulA gene sequence is available as EMBL accession no. U16156. Identical residues are indicated by dots, while asterisks have been inserted where insertions or duplications have been detected to allow sequence alignment. The amino acid sequence has been translated and appears above the nucleotide sequence. Amino acids that are conserved in all DHPS sequences are highlighted.