. 2022 Mar 2;10(3):585. doi: 10.3390/biomedicines10030585

Table 3.

NRI, IDI, AIC, BIC and adjusted R² for the combined assessment of eGFR and Gal-3 in predicting kidney disease progression.

	NRI and IDI Model Comparison
	NRI	95% CI		p Value ^†	IDI	95% CI		p Value ^†
Model 1: eGFR	-	-		-	-	-		-
Model 2: eGFR + Urinary Gal-3	0.5395	0.3133–0.7657		<0.001	0.0626	0.0344–0.0907		<0.001
Model 3: eGFR + Plasma Gal-3	0.7333	0.5172–0.9494		<0.001	0.0633	0.0333–0.0934		<0.001
Model 4: eGFR + Urinary Gal-3 + Plasma Gal-3	0.6040	0.3805–0.8277		<0.001	0.0909	0.0564–0.1254		<0.001
	AIC and BIC and R Square Model Comparison
	AIC		BIC		Adjusted R²		p Value
Model 1: eGFR	287.6032		298.5076		0.3541		<0.001
Model 2: eGFR + Urinary Gal-3	269.3027		283.8419		0.3971		<0.001
Model 3: eGFR + Plasma Gal-3	267.0637		281.6029		0.4019		<0.001
Model 4: eGFR + Urinary Gal-3 + Plasma Gal-3	264.8257		282.9997		0.4088		<0.001

^†p value vs. model 1. Abbreviations: NRI, net reclassification improvement; IDI, integrated discrimination improvement; AIC, Akaike information; BIC, Bayesian information criterion; eGFR, estimated glomerular filtration rate; Gal-3, galectin-3; CI, confidence interval.