Table 1.

Biomaterial-based immunomodulators, reproduced from Wright JB, Lam K, Buret AG, Olson ME, Burrell RE. Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Repair Regen 2002; 10:141–151.) and Forlee M, Rossington A, Searle R. A prospective, open, multicenter study to evaluate a new gelling fiber dressing containing silver in the management of venous leg ulcers. Int Wound J 2014; 11:438–445.

Pharmaceutical	Effect	Outcomes	Species
Silver and Gold dressings	Antimicrobial, Inhibit MMPs, Formation of granulation tissue	Augumentation of wound healing	Daily Practice available
Si-RNA	Regulation of immune cell infiltration + Subside protease activity	Amelioration of wound closure	Diabetic mouse
MiR-99	Regulation of PI3k/AKT pathway	Increase wound closure	Diabetic mouse
MALP-2	Infiltration of macrophages and activation	Influence early wound closure	Diabetic mouse
PRP gel	Source of cytokines and growth factors	Boost healing in diabetic ulcer	Phase I