Table 4.
A summary of the IC50 values, luminescent properties and special features of rhenium(I) luminescent complexes: phosphine ligated complex RE1 [93], GHS-responsive bio-sensing complex RE2 [94], mitochondrial-targeted theragnostic complex RE3 [96], rhenium(I) aqua complex RE5 [98], heterodinuclear Re(I) β-carboline complex RE7 [100], and gold(II)/rhenium(I) heterodinuclear complex RE8 [102].
| Re Complex |
HeLa IC50 (μM) | A549 IC50 (μM) | Luminescence | Special Features | |||
|---|---|---|---|---|---|---|---|
| Dark | Light (Irradiation nm) |
Dark | Light (Irradiation nm) |
λEm (nm) | λEx (nm) | ||
| RE1 | >200 | 5.9 ± 1.4 (365) | 516 | ~360 | The phosphine ligand regulated luminescence, which strongly correlated to cytotoxicity. | ||
| RE2 | 6.50 ± 2.0 | 541 | 405 | Showed significant emission enhancement when in the presence of GHS. | |||
| RE3 | 0.52 ± 0.07 | 3.4 ± 0.6 | 540 | 405 | Effective repression of mitochondrial metabolism; had O2-sensitive phosphorescent lifetimes | ||
| RE5 | 6.7 ± 4.9 | 560–590 | Induced caspase-independent cell death accompanied by cytoplasmic vacuolization. | ||||
| RE7 | 4.0 ± 0.6 | 15.8 ± 10 | 0.26 ± 0.04 (425) | ~550 | 405 | Homodinuclear Re(I) for chemo-photodynamic therapy. | |
| RE8 | 12.18 ± 1.19 | 4.48 ± 0.71 (405) | 460-514 | 414 | Heterodinuclear Au(II)–Re(I) complex; gold brought additional bioactivity. | ||