Table 3.

Power and medical costs using AWA, Accuracy or AUC in comparing two diagnostic tests from the same sample. The biomarker values from the two diagnostic tests in the infected population are distributed as N(μ₁=0.6,σ₁=1) and N(μ₂=0.5,σ₂=0.5), respectively.

Method	Sample Size (N)	Relative Importance (r)	Prevalence Range (p)	Prevalence rate	Threshold (Dx1)	Sensitivity (Dx1)	Specificity (Dx1)	AWA, Accuracy or AUC (Dx1)	Threshold (Dx2)	Sensitivity (Dx2)	Specificity (Dx2)	AWA, Accuracy or AUC (Dx2)	SD (Dx1-Dx2)	Power	Medical Cost (Dx1)	Medical Cost (Dx2)
AWA	500	0.25	5%−10%	0.075	2.189	0.056	0.986	0.759	0.817	0.263	0.949	0.782	0.0197	0.309	37.01875	33.534375
	500	0.25	10%−30%	0.200	0.366	0.592	0.643	0.618	0.27	0.677	0.705	0.692	0.0307	0.773	76.5	61.8
	500	0.1	5%−10%	0.075	0.677	0.469	0.751	0.626	0.363	0.608	0.766	0.696	0.0436	0.485	31.42875	25.5225
	500	0.1	10%−30%	0.200	−1.11	0.956	0.134	0.709	−0.173	0.911	0.365	0.747	0.0232	0.489	39.04	34.3
	1000	0.25	5%−10%	0.075	2.189	0.056	0.986	0.759	0.817	0.263	0.949	0.782	0.0139	0.491	74.0375	67.06875
	1000	0.25	10%−30%	0.200	0.366	0.592	0.643	0.618	0.27	0.677	0.705	0.692	0.0217	0.959	153	123.6
	1000	0.1	5%−10%	0.075	0.6	0.5	0.726	0.626	0.363	0.608	0.766	0.696	0.0308	0.738	62.845	51.045
	1000	0.1	10%−30%	0.200	−1.11	0.956	0.134	0.709	−0.173	0.911	0.365	0.747	0.0164	0.74	78.08	68.6
Accuracy	500	0.25	5%−10%	0.075	3	0.008	0.999	0.924	1.506	0.022	0.999	0.925	0.0029	0.102	37.315625	36.790625
	500	0.25	10%−30%	0.200	2.61	0.022	0.995	0.801	0.943	0.188	0.97	0.814	0.0105	0.342	98.3	84.2
	500	0.1	5%−10%	0.075	3	0.008	0.999	0.924	1.506	0.022	0.999	0.925	0.0029	0.102	37.24625	36.72125
	500	0.1	10%−30%	0.200	2.61	0.022	0.995	0.801	0.943	0.188	0.97	0.814	0.0105	0.342	98	82.4
	1000	0.25	5%−10%	0.075	3	0.008	0.999	0.924	1.506	0.022	0.999	0.925	0.0021	0.132	74.63125	73.58125
	1000	0.25	10%−30%	0.200	2.61	0.022	0.995	0.801	0.943	0.188	0.97	0.814	0.0074	0.542	196.6	168.4
	1000	0.1	5%−10%	0.075	3	0.008	0.999	0.924	1.506	0.022	0.999	0.925	0.0021	0.132	74.4925	73.4425
	1000	0.1	10%−30%	0.200	2.61	0.022	0.995	0.801	0.943	0.188	0.97	0.814	0.0074	0.542	196	164.8
AUC	500	0.25	5%−10%	0.075				0.664				0.76	0.0491	0.621	153.125	153.125
	500	0.25	10%−30%	0.200				0.664				0.76	0.032	0.911	200	200
	500	0.1	5%−10%	0.075				0.664				0.76	0.0491	0.621	83.75	83.75
	500	0.1	10%−30%	0.200				0.664				0.76	0.032	0.911	140	140
	1000	0.25	5%−10%	0.075				0.664				0.76	0.0491	0.868	306.25	306.25
	1000	0.25	10%−30%	0.200				0.664				0.76	0.0226	0.995	400	400
	1000	0.1	5%−10%	0.075				0.664				0.76	0.0347	0.868	167.5	167.5
	1000	0.1	10%−30%	0.200				0.664				0.76	0.0226	0.995	280	280