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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: IEEE Trans Biomed Eng. 2022 Mar 18;69(4):1481–1490. doi: 10.1109/TBME.2021.3120919

Fig. 2.

Fig. 2.

Simulated −6 dB focal regions through clinical CT vs micro-CT scans of an (a) NHP skull fragment and (b) a human skull fragment. White asterisks and cyan circles denote the 0 dB center of the focus simulated in free field, and through skulls, respectively. dB scale on color bar is self-normalized for each pressure plot. (c) A significant increase in pressure attenuation through an NHP skull fragment was observed in the simulation using a micro-CT compared to the clinical CT scan (****p<0.0001). (d) A significant increase in pressure attenuation through the human skull fragment was also observed using the micro-CT compared to the clinical CT scan (**p<0.01). (e) A significant decrease in axial focal shift was observed in the micro-CT simulation relative to the clinical CT simulation (**p<0.01) for the NHP skull, while (f) no statistically significant differences in focal shift were observed for the human skull. These results were determined by an unpaired Student’s t-test with n=6 lateral/elevational transducer positions. (g) Axial (top) and lateral (bottom) simulated focus profiles in free field (dashed line), through NHP skull, and human skull using micro-CT scans shown in (a-b). (h) Experimentally-determined axial (top) and lateral (bottom) focus profiles in free field, through NHP skull, and human skull.