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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: IEEE Trans Biomed Eng. 2022 Mar 18;69(4):1481–1490. doi: 10.1109/TBME.2021.3120919

Fig. 6.

Fig. 6.

Reversibility and safety of TUS-mediated BBB opening. Representative T1-weighted MRI acquired 7 hours after TUS for (A) NHP skull and (B) human skull sonications depicting lack of contrast enhancement in regions of BBB opening (in Fig. 5A-B). Representative coronal H&E-stained brain slices of mouse brains sonicated bilaterally with an overlaid NHP skull fragment (C) or human skull fragment (D). No signs of damage were observed in any H&E-stained brain sections. Scale bars denote 1500 μm.