Table 1.
Patient characteristics
| Characteristic | Adult program (n = 415) |
Pediatric program (n = 139) |
Overall (N = 554) |
|---|---|---|---|
| Median age at transplant, years | 56 (45-64; 20-73) | 12 (7-19; 0-44) | 49 (25-62; 0-73) |
| Age group, years | |||
| <20 | 1 (0.2) | 105 (76) | 106 (19) |
| 20-40 | 77 (19) | 33 (24) | 110 (20) |
| 40-60 | 173 (42) | 1 (0.7) | 174 (31) |
| and ≥ 60 | 164 (40) | 0 (0) | 164 (30) |
| Sex | |||
| Female | 187 (45) | 52 (37) | 239 (43) |
| Male | 228 (55) | 87 (63) | 315 (57) |
| Disease | |||
| Leukemia | 274 (66) | 80 (58) | 354 (64) |
| Leukemia (second primary) | 1 (0.2) | 2 (1.3) | 3 (0.5) |
| Myelodysplastic syndrome | 112 (27) | 17 (12) | 129 (23.3) |
| Myeloproliferative disorder | 23 (5.5) | 0 (0) | 23 (4.2) |
| Non-Hodgkin lymphoma | 5 (1.2) | 1 (0.7) | 6 (1.1) |
| Nonmalignant hematologic disorders | 0 (0) | 39 (28) | 39 (7) |
| Malignancy | |||
| Malignant | 415 (100) | 100 (72) | 515 (93) |
| Nonmalignant | 0 (0) | 39 (28) | 39 (7.0) |
| TBI-based conditioning regimen | 136 (33) | 41 (41) | 177 (34) |
| Donor type | |||
| MMRD | 2 (0.5) | 15 (11) | 17 (3.1) |
| MMUD | 61 (15) | 51 (37) | 112 (20) |
| MRD | 150 (36) | 24 (17) | 174 (31) |
| MUD | 202 (49) | 49 (35) | 251 (45) |
| CMV match | |||
| R–/D– | 118 (29) | 40 (29) | 158 (29) |
| R–/D+ | 43 (11) | 19 (14) | 62 (11) |
| R+/D– | 101 (25) | 25 (18) | 126 (23) |
| R+/D+ | 142 (35) | 55 (40) | 197 (36) |
| Unknown | 11 | 0 | 11 |
| HCT Comorbidity Index score | |||
| 0-1 | 162 (39) | 74 (53) | 236 (43) |
| 2-3 | 160 (39) | 45 (32) | 205 (37) |
| 4-10 | 93 (22) | 20 (14) | 113 (20) |
| DRI | |||
| High | 47 (13) | 16 (18) | 63 (14) |
| Intermediate | 284 (80) | 57 (63) | 341 (77) |
| Low | 22 (6) | 18 (20) | 40 (9) |
| Unknown | 62 | 48 | 110 |
| Post-HCT rATG exposure | 48 (43-53; 17-101) | 35 (21-48; 0-87) | 47 (40-52; 0-101) |
Statistics presented are No. (%) for categorical variables, and median (interquartile range, range) for the continuous variables.
D, donor; MMRD, mismatched related donor; MMUD, mismatched unrelated donor; MRD, matched related donor; MUD, matched unrelated donor; R, recipient; DRI, Disease Related Index; CMV, Cytomegalovirus; rATG, rabbit antithymocyte globulin.