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. 2022 Feb 28;10(3):561. doi: 10.3390/biomedicines10030561

Figure 1.

Figure 1

SNPs in linkage disequilibrium with the human MCHR1 gene that have been shown to exhibit various degrees of association with psychotic disorders, arranged as haplotypes with respect to rs133073 as determined by in silico analysis of the CEU population database (LDpop). Note that the allele of risk for *rs5758209 was not specified in the study by the Schizophrenia Working Group [68]. The alleles of risk from two small studies and one large study—in orange font—cluster on the upper haplotype and correspond to combined results from: a Scottish population, Severinsen et al. [62]: rs133068-70, -73; a Danish population, Demontis et al. [67]: rs133054-70, -72-73; a population of predominantly mixed European ancestry, Mullins et al. [69]: rs5758064; and a population of predominantly mixed European ancestry, Schizophrenia Working Group [68]: *rs5758209. Where the risk data from the Scottish population and the Danish population did not match, both alleles are coded blue. The risk alleles identified in a Severinsen et al. study [62] for the far northern population isolate on the Faroe Islands, are shown on the lower in silico haplotype for rs133068-70,-73. A founder effect may have resulted in a higher prevalence of the C allele for rs133073 in the controls studied in this isolated population, 50% as compared to the rate the authors reported for Scotland (41%) and in current LDpop data for the UK (36%), but it is likely that the haplotype containing the T allele was selected for over time, with the evolutionary tradeoff being more schizophrenia cases, becoming markedly more prevalent (1.6-fold) in the Faroe Island cases than in controls.