Table 6.
Diagnostic accuracy of IVIM- and DCE-derived parameters.
| Sensitivity % | 95% CI | Specificity % | 95% CI | PPV % | 95% CI | NPV % | 95% CI | Accuracy % | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADC | 88.9 | 79.8–97.7 | 100 | 88.8–100 | 100 | NA | 91.0 | 77.7–96.7 | 94.8 | 85.6–98.9 | |
| IVIM | D | 81.5 | 61.9–93.7 | 87.1 | 70.2–96.4 | 84.9 | 68.8–93.4 | 84.1 | 70.4–92.2 | 84.5 | 72.6–92.6 |
| D* | 85.2 | 66.3–95.8 | 70.9 | 52.0–85.8 | 72.24 | 59.5–82.2 | 84.4 | 68.0–93.2 | 77.7 | 64.8–87.5 | |
| FP | 48.2 | 28.7–68.1 | 93.6 | 78.6–99.2 | 86.9 | 62.1–96.4 | 67.1 | 58.3–74.8 | 72.2 | 58.9–83.2 | |
| Permeability | Ktrans | 44.4 | 25.5–64.7 | 100 | 88.8–100 | 100 | NA | 66.9 | 59.2–73.9 | 73.9 | 60.7–84.5 |
| Kep | 88.9 | 70.8–97.7 | 96.8 | 83.3–99.9 | 96.1 | 77.9–99.4 | 90.1 | 77.1–96.6 | 93.1 | 83.2–98.1 | |
| Ve | 85.2 | 66.3–95.8 | 100 | 88.8–100 | 100 | NA | 88.4 | 75.5–94.9 | 93.1 | 83.2–98.1 | |
| iAUC | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
ADC: apparent diffusion coefficient; IVIM: incoherent voxel motion; CI: confidence interval; D: pure diffusion coefficient; D*: pseudo-diffusion coefficient; FP: fraction perfusion; Ktrans: transfer constant; Kep: reflux constant; Ve: extra-vascular extra-cellular volume fraction; iAUC: initial area under curve in 60 s.