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. 2022 Mar 18;11(3):581. doi: 10.3390/antiox11030581

Figure 9.

Figure 9

Scheme showing the effects of squalene on cells involved in oxidative and ER stress in the presence and absence of TXNDC5. In presence of squalene, wild-type and TXNDC5 deficient AML12 cell lines were exposed to oxidative and ER stress. The scheme reveals that in absence of TXNDC5, ROS abundance and Gpx4 mRNA expression are enhanced, and Eif2ak3 expression is decreased; whereas, in presence of TXNDC5, the ROS amount and Ern1 mRNA level are reduced. This scheme was designed using Microsoft Publisher Document version 2010. ↑Increased,↓Decreased.