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. 2022 Mar 1;10(3):574. doi: 10.3390/biomedicines10030574

Figure 2.

Figure 2

Schematic representation of the Nrf2/ARE signaling pathway. Under the influence of reactive oxygen species (ROS), the Nrf2/ARE complex dissociates and Nrf2 translocates to the nucleus, where it triggers the expression of genes with ARE (antioxidant response element) sequence in their promoters, leading to the production of endogenous antioxidants such as glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GSH), and catalase (CAT). Adapted from Vasconcelos et al. [109].