Table 1.
Pathways of neuroprotection and neuronal injury mediated by sirtuins.
| Pathways of Cerebral Tissue Protection Following Ischemia | Sirtuins Involved |
|---|---|
| Reduces oxidative stress | SIRT 1, 3, 6 |
| Promotes glutamate uptake | SIRT 4 |
| Increased calcium buffering | SIRT 3 |
| Preserves mitochondrial respiration | SIRT 1, 3, 5 |
| Maintains ATP levels | SIRT 3, 4 |
| Promotes neural stem cell proliferation | SIRT 1, 2 |
| Promotes neural stem cell differentiation | SIRT 1, 2, 6 |
| Preserves blood flow | SIRT 1 |
| Maintains blood brain barrier integrity | SIRT 3 |
| DNA repair | SIRT 1 |
| Reduces inflammation | SIRT 1 |
| Mediates neuroprotective effects of NAD+ | SIRT 1, 5 |
| Pathways of Cerebral Injury Following Ischemia | Sirtuins Involved |
| Increases oxidative stress | SIRT 2, 3, 6 |
| Damages mitochondrial respiration | SIRT 3 |
| Increases autophagy | SIRT 6 |
| Induces axonal injury | SIRT 2 |