Figure 1.

Measurement of IL6 and chemokines by ELSIA in rat serum after TO injection administered intramuscularly into the right and left hindlimb of rats at a concentration of 5 mL/kg. The data are compared with the controls (co), which received only saline into both hindlimbs. Both the treated and control animals were sacrificed at 1, 2, 4, 6, 12, 24, and 48 h after injection. Results represent the mean ± SEM values compared with saline-treated controls for each time point (analyzed by one-way ANOVA analysis of variance, n = 6). Significance was accepted at * p ≤ 0.05, ** p ≤ 0.01.