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. 2022 Mar 18;11(3):583. doi: 10.3390/antiox11030583

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Multivariate analysis and metabolic network of the significantly changed endogenous metabolites. (A) PCA score plots of the sham, MI, and MI treated with 0.75 mg/kg RUS groups. (B) OPLS-DA score plots of the MI and MI treated with 0.75 mg/kg RUS groups. (C) Heat map of 62 differential endogenous metabolites in urine and serum (n = 6). (D) The metabolic network map of the differential metabolites and their changed metabolic pathways. Red metabolites in the network are increased in the RUS group compared with the MI group and the down-regulated metabolites are represented by green.