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. 2022 Mar 18;11(3):583. doi: 10.3390/antiox11030583

Figure 8.

Figure 8

BCAT1 or BCAT2 knockdown partially weakened the protective effect of RUS in OGD-injured H9c2 cardiomyocytes. (A) The cell viability of H9c2 cardiomyocytes after being transfected with BCAT1 siRNA (n = 6). (B) Western blotting analysis of GPX4, ACSL4, and FTL in H9c2 cardiomyocytes transfected with BCAT1 siRNA (n = 3). (C) The cell viability of H9c2 cardiomyocytes after being transfected with BCAT2 siRNA (n = 6). (D) Western blotting analysis of GPX4, ACSL4, and FTL in H9c2 cardiomyocytes transfected with BCAT2 siRNA (n = 3). Western blotting analysis of Keap1, Nrf2 and HO-1 in H9c2 cardiomyocytes transfected with (E) BCAT1 siRNA or (F) BCAT2 siRNA (n = 3). Results were expressed as mean ± SD. * p  <  0.05, ** p  <  0.01 vs. the OGD group, $ p  <  0.05, $$ p  <  0.01 vs. the group treated with RUS and OGD, Ұ p  <  0.05, ҰҰ p  <  0.01 vs. the group treated with OGD and BCAT1 siRNA or BCAT2 siRNA.