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. 2022 Mar 2;12(3):391. doi: 10.3390/biom12030391

Figure 3.

Figure 3

COL11A1 activated the serine-threonine kinase (AKT)/glycogen synthase kinase (GSK)-3β/Snail signaling pathway: (A) expression levels of AKT, GSK-3β, phosphor (p)-AKTSer473, p-GSK-3βSer9, and Snail in PANC-1 cells transfected with pCMV3-COL11A1 or siCOL11A1 were measured by Western blotting; (B) Western blotting results showing the expression levels of AKT, GSK-3β, p-AKTSer473, p-GSK-3βSer9, and Snail in PANC-1 cells treated with pCMV3-COL11A1 and LY294002; (C) immunofluorescence analysis of Snail expression by confocal microscopy in PANC-1 cells transfected with pCMV3-COL11A1, siCOL11A1, and/or LY294002, siGSK-3β(×100) (n = 3, * p < 0.05).