Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 2;12(3):391. doi: 10.3390/biom12030391

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

COL11A1 promoted EMT via the AKT/GSK-3β/Snail signaling pathway: (A) Western blotting results showing the expression levels of EMT markers and MMP-2/9 in PANC-1 cells transfected with pCMV3-COL11A1, LY294002, and siGSK-3β; (B) the sequence and position of the Snail binding site in the E-cad promoter are shown. Chromatin immunoprecipitation (ChIP) of Snail in the E-cad promoter. PANC-1 cells were transfected withpCMV3-COL11A1, siCOL11A1, siGSK-3β, and LY294002; (C) immunofluorescence analysis of E-cad expression levels in PANC-1 cells transfected with pCMV3-COL11A1, LY294002, siGSK-3β, and siSnail (×100); (D) the images show the adhesion ability of the indicated cells after different treatments. (n = 3, * p < 0.05).