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. 2022 Mar 3;10(3):601. doi: 10.3390/biomedicines10030601

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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BGJ 398 potentiates accumulation of Tx-R HCC 1806 cancer cells in M-phase after the treatment with PTX. Immunoblot analysis for phospho-NuMA (Ser395) and phospho-H3 (Ser10) in the parental (A) and Tx-R (B) HCC 1806 breast cancer cells after treatment with DMSO (negative control), BGJ 398, PTX alone or in combination for 48 h. Actin stain is used as a loading control. (C,D) Quantification by mean pixel density of pNuMA (Ser395) and pH3 (Ser10) in the parental (C) and Tx-R (D) HCC 1806 breast cancer cells. Values are means ± SD, n = 3. * p < 0.05 vs. untreated cells.