Table 1.
IC50 values for PTX and Dox in parental and Tx-R triple-negative breast cancer (TNBC) and gastrointestinal stromal tumor (GIST) cell lines.
Chemical Compounds | Cell Line | Parental | Tx-R | Fold Increase |
---|---|---|---|---|
PTX (µM) | HCC 1806 | 0.22 ± 0.01 | 5.4 ± 1 | 24.5 |
GIST T-1 | <0.01 | 0.46 ± 0.08 | >46 | |
Dox (µM) | HCC 1806 | 0.22 ± 0.004 | 1.8 ± 0.5 | 81.8 |
GIST T-1 | 0.04 ± 0.005 | 6.5 ± 1 | 162.5 | |
BGJ 398 (µM) | HCC 1806 | 12 ± 1.3 | 17.6 ± 3 | 1.47 |
GIST T-1 | 8.8 ± 1 | 7.2 ± 0.2 | 0.82 |