Table 1.
Patient demographics and clinical characteristics at diagnosis by frontline therapy
| Total (N = 244) |
Conventional* (n = 190) |
Other (n = 54) |
|||||
|---|---|---|---|---|---|---|---|
| Characteristic | n | % | n | % | n | % | P † |
| Male sex | 113 | 46.3 | 85 | 44.7 | 28 | 51.9 | .36 |
| Age, y | .004 | ||||||
| Median | 68 | 67 | 73 | ||||
| Range | 60 to ≥90 | 60-88 | 60 to ≥90 | ||||
| Age category, y | |||||||
| 60-69 | 140 | 57.4 | 123 | 64.7 | 18 | 33.3 | Ref |
| 70-79 | 79 | 32.4 | 55 | 28.9 | 24 | 44.4 | .7 |
| ≥80 | 24 | 9.8 | 12 | 6.3 | 12 | 22.2 | .002 |
| Stage | |||||||
| Limited (I-II) | 89 | 36.5 | 70 | 36.8 | 19 | 35.2 | Ref |
| Advanced (III-IV) | 155 | 63.5 | 120 | 63.2 | 35 | 64.8 | .77 |
| B symptoms present | 112 | 45.9 | 95 | 50.0 | 17 | 31.5 | .01 |
| ECOG PS | |||||||
| 0-2 | 214 | 87.7 | 166 | 87.4 | 48 | 88.9 | Ref |
| 3-4 | 8 | 3.3 | 6 | 3.2 | 2 | 3.7 | .03 |
| Unknown/missing data | 22 | 9.0 | 18 | 9.4 | 4 | 7.4 | .65 |
| Impaired ADLs/instrumental ADLs at baseline | |||||||
| No | 206 | 84.4 | 163 | 85.9 | 43 | 79.6 | Ref |
| Yes | 30 | 12.3 | 19 | 10.0 | 11 | 20.4 | .054 |
| Unknown/missing data | 8 | 3.3 | 8 | 4.2 | 0 | 0 | — |
| Geriatric syndrome at baseline | |||||||
| No | 195 | 79.9 | 156 | 82.1 | 39 | 72.2 | Ref |
| Yes | 43 | 17.6 | 28 | 14.7 | 15 | 27.8 | .03 |
| Unknown/missing data | 6 | 2.5 | 6 | 3.2 | 0 | 0 | — |
| CIRS-G total score | |||||||
| <10 | 196 | 80.3 | 153 | 80.5 | 43 | 79.6 | Ref |
| ≥10 | 48 | 19.7 | 37 | 19.5 | 11 | 20.4 | .02 |
| Unknown/missing data | 0 | 0 | 0 | 0 | 0 | 0 | — |
*
Conventional cHL regimens included AVD, ABVD, BV plus AVD (concurrent or sequential), and Stanford V.
†
All P values are 2 sided.