Table 2.
BBB permeability surface product, cerebral blood flow, cerebral volume, and mean transit time measurements at the time of remission (month 0) and 6 months later (month 6)
| Month 0 (N = 7) | Month 6 (N = 7) | Mean change(95% CI) | P * | |
|---|---|---|---|---|
| PS (ml/min/100 g), weighted average (mean [SD]) | ||||
| Right side | 0.92 (0.32) | 0.61 (0.22) | −0.3075 (−0.4428, −0.1722) | .0014 |
| Left side | 0.89 (0.29) | 0.58 (0.23) | −0.3138 (−0.5122, −0.1155) | .0083 |
| Overall† | 0.91 (0.30) | 0.59 (0.22) | −0.3119 (−0.4729, −0.1510) | .0032 |
| CBF (ml/100 g), weighted average (mean [SD]) | ||||
| Right side | 46.8 (4.7) | 43.2 (2.8) | −3.5709 (−8.9584, 1.8165) | .1560 |
| Left side | 47.8 (5.8) | 43.3 (4.9) | −4.5457 (−9.5221, 0.4307) | .0668 |
| Overall† | 48.2 (3.9) | 44.1 (4.0) | −4.0461 (−9.0938, 1.0015) | .0975 |
| CBV (ml/100 g), weighted average (mean [SD]) | ||||
| Right side | 2.84 (0.30) | 2.61 (0.24) | −0.2313 (−0.5939, 0.1314) | .1696 |
| Left side | 2.91 (0.32) | 2.60 (0.38) | −0.3041 (−0.6141, 0.0060) | .0533 |
| Overall† | 2.93 (0.25) | 2.66 (0.32) | −0.2699 (−0.5957, 0.0559) | .0890 |
| MTT (s), weighted average (mean [SD]) | ||||
| Right side | 3.65 (0.12) | 3.62 (0.13) | −0.0275 (0.1801, 0.1250) | .6743 |
| Left side | 3.66 (0.11) | 3.60 (0.14) | −0.0610 (−0.2210, 0.0989) | .3865 |
| Overall† | 3.73 (0.25) | 3.68 (0.19) | −0.0488 (−0.2086, 0.1110) | .4833 |
Results are presented as mean (standard deviation). There are no missing values. CBF, cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time.
*
A one-sample t test was used to test whether the mean change in each outcome was significantly different from zero.
†
The overall value is calculated as the weighted average of both the right and left sides.