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Evaluation of CNN-XG for on-target profile prediction. (a–c) Comparison of sgRNA on-target efficacy predictions for HCT116, HELA, HEK293T and HCT116 in 10-fold cross-validation in classification mode and regression mode. (d,e) Comparison of sgRNA on-target efficacy predictions in regression and classification schema for various datasets, i.e., HCT116 cell line, HELA cell line, HEK293T cell line, HCT116 cell line. (f) The result of a generalization ability test in new cell lines.
