Figure 3.

Time to attain dominance of E cells depends on initial fraction and average doubling times of phenotypes, and the extent of molecular fluctuations. (A) Temporal changes in phenotypic distribution for purely E, E/M, and M initial population. (B) Temporal changes in phenotypic distribution when there is heterogeneity in average doubling time (DT) among phenotypes. DT(E/M, M) = DT ratio ∗ DT(E). η₁ = 0.2, and η₂ = 0.1. (C) Temporal changes in phenotypic distribution for fixed η₁ and varying η₂ values. Here, DT(E, E/M, M) = 20 h. (D) Same as (C) but with varying η₁ and fixed η₂ values. In all, except (A), initial fractions of (1) Mix of E/M and M, and (2) pure E phenotypes are considered. The initial population size was 200 cells. Mean and standard deviation calculated from 16 independent runs.