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Goals and definitions for HBV therapies.
| Response | Blood | Liver | |||
|---|---|---|---|---|---|
| ALT | HBV DNA | HBsAg | Anti-HBs | cccDNA | |
| Virologic | normal | undetectable | detected | undetectable | present |
| Biochemical | normal | N/A | detected | undetectable | present |
| Functional cure | normal | undetectable | undetectable | detected | present |
| Complete cure | normal | undetectable | undetectable | detected | undetectable |
ALT: alanine aminotransferase; anti-HBs: anti-HBsAg antibodies, cccDNA: covalently closed circular DNA, HBsAg: Hepatitis B surface Antigen.
