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. 2022 Mar 1;10(3):580. doi: 10.3390/biomedicines10030580

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chronological detection of DNA pol mutants arising at different passages under pressure of HPMPC (A), HPMPDAP (B), and HPMPO-DAPy (C). Viral clones were isolated at different passages during the selection procedure and genotyping of the E9L (DNA pol) gene was carried out. The percentage of clones harboring a specific mutation is shown for the different passages.

Chronological detection of DNA pol mutants arising at different passages under pressure of HPMPC (A), HPMPDAP (B), and HPMPO-DAPy (C). Viral clones were isolated at different passages during the selection procedure and genotyping of the E9L (DNA pol) gene was carried out. The percentage of clones harboring a specific mutation is shown for the different passages.