Table 1.
Drug | Amino Acid Changes in Viral DNA Polymerase | |||
---|---|---|---|---|
Known Natural Occurring Genetic Polymorphisms | Known Drug-Resistant Mutations (Dark Blue) and Novel Mutations (Yellow) | |||
HPMPA | T845M, G857R, 936–938 ANV | A314T | — | — |
cHPMPA | T845M, G857R, 936–938 ANV | — | A353V | S851Y |
cHPMPC | T845M, G857R, 936–938 NΔG | A314T | — | — |
The complete DNA pol (E9L gene) was genotyped for one of the viral clones isolated from each selection procedure with the indicated drug. The presence of the mutations was verified in additional viral clones, encompassing 8 viral clones selected under HPMPA and cHPMPA and 9 viral clones under cHPMPC.