Table 2.
Identification of amino acid changes in the CPXV Brighton strain DNA polymerase following selective pressure with HPMPC, HPMPDAP, and HPMPO-DAPy.
| Drug | Amino Acid Changes in Viral DNA Polymerase | |||||
|---|---|---|---|---|---|---|
| Known Natural Occurring Genetic Polymorphisms | Known Drug-R Mutations (Dark Blue) and Novel Mutations (Yellow) | |||||
| HPMPC (clones 1, 2, 4, 5, 6, 7) | — | A314V | — | A684V | — | — |
| HPMPDAP (clones 1, 2, 3) | — | — | Ins408 (amino acids KDIICKVIH) | — | — | L924F |
| HPMPDAP (clones 4, 5, 6, 7, 8) | — | — | — | — | — | L924F |
| HPMPO-DAPy (clones 1, 4, 5, 6, 7) | — | — | — | — | Ins851L | — |