Table 1.
CSF Administration Method | IV Administration Method | |
---|---|---|
Infusion rate (mg/kg/h) | 4 | 350 |
Number of animals | 3 for each sampling time | 3 for each sampling time |
Infusion time (min) | 60 | 60 |
Collected sample | CSF, Brain Part I, Brain Part II |
CSF, Brain |
Sampling time (min) after end of infusion | 60, 120, 180, and 240 min | 60, 120, 180, 240, 300, and 360 min |