Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Early metastatic cascade.
| Step | Characteristics |
|---|---|
| Premetastatic niche | Inflammation, immunosuppression, organotropism, ECM-reprogramming, angiogenesis, vascular permeability |
| Intravasation | Proteases, signalling molecules: TGFβ, EGF-receptor |
| Transport | Mechanical stress, interaction with blood components |
| Docking | Mechanical, selectin & integrin binding |
| Extravasion | EMT, mesenchymal/amoeboid transition |
| Colonisation | Dormancy, vascular network formation, immune response |
