Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of resistance to polyADP-ribose polymerase (PARP) inhibitors. Several resistance mechanisms have been identified: reversion mutation, DNA polymerase θ (POLQ), loss of shieldin complex, stabilization of replication fork, increased drug efflux, overexpression of cyclin-dependent kinase 12 (CDK12) and WEE1.
