Table 1.

Trial Design for FAST and FAST-Forward Trial [13,14,15,16,17].

	FAST	FAST-Forward
Timeframe	2004–2007	2011–2014
Sample Size	915	4096
Arms	50 Gy/2 Gy/5 weeks	40 Gy/2.67 Gy/3 weeks
	30 Gy/6 Gy/5 weeks	27 Gy/5.4 Gy/1 week
	28.5 Gy/5.7 Gy/5 weeks	26 Gy/5.2 Gy/1 week
Primary endpoint	Photographic appearance	Ipsilateral tumor recurrence
Statistical design	Non-inferiority	Non-inferiority
Eligibility Criteria	pT1–2 (<3 cm) pN0	pT1–3 pN0–1
	Age ≥ 50 years	Age ≥ 18 years
	BCS	BCS or mastectomy
	No chemotherapy	Chemotherapy allowed
Median follow-up	9.9 years	5.9 years

BCS: breast conserving surgery.