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. 2022 Mar 8;11(6):927. doi: 10.3390/cells11060927

Figure 6.

Figure 6

HCV or HEV super-infections on HEV- or HCV-infected humanized mice. (A) Human liver chimeric uPA+/+-SCID mice were injected intraperitoneally with HEV and subsequently injected intravenously with HCV (black dashed line). HEV RNA (green data points) and HCV RNA (red data points) were periodically measured. Left panel: HEV viral loads of HEV mono-infected mice. Right panel: HEV viral loads of HEV co-infected animals as well as mean HCV titers of HCV mono-infected (semitransparent data points) and HCV titers of HCV co-infected mice. Green dashed line and red dashed line indicate the limit of detection (LOD) of the HEV or HCV RT qPCR, respectively. (B) Human liver chimeric uPA+/+-SCID mice were injected intravenously with HCV and subsequently injected intraperitoneally with HEV (black dashed line). HEV RNA (green data points) and HCV RNA (red data points) were periodically measured. Left panel: HCV viral loads of HCV mono-infected mice. Right panel: HCV titers of HCV co-infected animals as well as mean HEV viral loads of HEV mono-infected (semitransparent data points) and HEV viral loads of HEV co infected mice. Green dashed line and red dashed line indicate the LOD of the HEV or HCV RT qPCR, respectively.