Table 1.
Follow-up of oncological patients: comparison of age and ovarian reserve between the time of cryostorage and follow-up.
| Cryostorage (t0) | Follow-Up (t1) | p t0 vs. t1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Patients (%) | AGE | AFC | AMH | FSH | AGE | AFC | AMH | FSH | |||
| Total Patients | 508 | 29.4 ± 4.0 | 7.1 ± 5.0 | 1.6 ± 0.8 | 13.1 ± 8.1 | 37.6 ± 5.6 | 2.8 ± 1.6 | 0.7 ± 0.3 | 34.5 ± 17.4 | Age t0–t1 0.001 AFC t0–t1 0.001 AMH t0–t1 0.001 FSH t0–t1 0.001 |
|
| Regular menses after chemotherapy 276/432 (64%) (a) | 276 | 28.5 ± 5.2 | 8.7 ± 2.2 | 1.6 ± 0.6 | 7.8 ± 4.5 | 38.1 ± 4.2 | 4.3 ± 2.8 | 1.3 ± 0.3 | 6.8 ± 2.9 | at t0 Age a vs. b 0.001 AFC a vs. b 0.001 AMH a vs. b 0.001 FSH a vs. b 0.001 |
|
| Natural conception (a1) | 75/276 (27%) | 29 ± 4.8 | 9.3 ± 3.8 | 1.9 ± 0.6 | 7.4 ± 3.2 | 39 ± 4.5 | 5.3 ± 3.2 | 1.5 ± 0.4 | 6.7 ± 4.5 | Age t0–t1 0.001 AFC t0–t1 0.001 AMH t0–t1 0.001 FSH t0–t1 0.274 |
|
| Not interested in becoming pregnant (a2) | 201/276 (73%) | 28.6 ± 6.7 | 8.2 ± 4.7 | 1.5 ± 0.9 | 9.5 ± 6.6 | 37.2 ± 4.3 | 4.5 ± 2.1 | 1.2 ± 0.5 | 7.2 ± 3.3 | Age t0–t1 0.001 AFC t0–t1 0.001 AMH t0–t1 0.001 FSH t0–t1 0.001 |
|
| POI after chemotherapy 156/432 (36%) (b) | 156 | 31.5 ± 4.8 | 7.2 ± 1.7 | 1.1 ± 0.7 | 9.1 ± 3.2 | 37.2 ± 4.9 | 0.4 ± 0.3 | 0.2 ± 0.1 | 63.2 ± 17.0 | at t1 Age a vs. b 0.044 AFC a vs. b 0.001 AMH a vs. b 0.001 FSH a vs. b 0.001 |
|
| Not interested in becoming pregnant (b1) | 112/156 (72%) | 32 ± 6.7 | 7.2 ± 1.8 | 1.3 ± 0.9 | 9.02 ± 5.4 | 38.5 ± 8.7 | 0.7 ± 0.5 | 0.03 ± 0.01 | 72.0 ± 43.0 | Age t0–t1 0.001 AFC t0–t1 0.001 AMH t0–t1 0.001 FSH t0–t1 0.001 |
|
| Trying to become pregnant with cryostored oocytes (b2) | 44/156 (28%) | 29.4 ± 4.0 | 7.3 ± 2.1 | 1.4 ± 0.8 | 9.3 ± 2.8 | 36.0 ± 5.1 | 0.5 ± 0.3 | 0.23 ± 0.11 | 56.0 ± 23.0 | Age t0–t1 0.001 AFC t0–t1 0.001 AMH t0–t1 0.001 FSH t0–t1 0.001 |
|
| Lost to follow-up (70) | 70/508 (14%) | 29.7 ± 3.5 | 8.6 ± 5.1 | 1.8 ± 0.7 | 7.7 ± 3.2 | - | - | - | - | ||
| Deceased (6) | 6/508 (1.2%) | 29.3 ± 2.1 | 5.1 ± 1.8 | 0.9 ± 0.3 | 10.1 ± 2.3 | - | - | - | - | ||
POI—premature ovarian insufficiency; AFC—antral follicle count; AMH—anti-Müllerian hormone.