Figure 1.

Schematic representation of canonical and non-canonical features of Granzyme B (GzmB). (a) Targeted killing of cancer cells by T cells through granule release while inhibiting self-inflicted damage caused by leaky granules. GzmB is introduced into a target cell leading to apoptosis. GzmB leaked into T cells is inhibited by Serpin9. (b) Extracellular interaction polarizes granules for release, resulting in cleavage of extracellular factors such as fibrinogen and laminin. These cleavages increase the rate of transmigration of T cells. Serpin9 = Serine Protease Inhibitor 9.