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. 2022 Mar 11;11(6):968. doi: 10.3390/cells11060968

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Alterations in the composition of bile acid-metabolizing bacteria in alcohol fed-mice. Control (Ctrl) and alcohol-fed (Alc) mice received a Lieber DeCarli diet with isocaloric maltodextrin or alcohol, respectively. Pectin-treated mice (Alc + p) received 6.5% pectin in addition to 5% ethanol. Human fecal microbiota transfer (FMT) groups received fecal microbial transplantations from a patient with alcoholic hepatitis. (A,B,D) Violin plots showing the relative abundance of bacteria with bile salt hydrolase (A,B) and 7 alpha-hydroxysteroid dehydrogenase (7-a-HSDH) activity (D) in all groups of mice (FDR p < 0.05). Predictive expression of bile salt hydrolase (C) and 7-a-HSDH (E). * p < 0.05, ** p <0.01, *** p < 0.001, **** p < 0.0001.