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. 2022 Mar 11;11(6):968. doi: 10.3390/cells11060968

Figure 6.

Figure 6

Alterations in sugar and lipid metabolism induced by pectin. Control (Ctrl) and alcohol-fed (Alc) mice received a Lieber DeCarli diet with isocaloric maltodextrin or alcohol, respectively. Pectin-treated mice (Alc + p) received 6.5% pectin in addition to 5% ethanol. Human fecal microbiota transfer (FMT) groups received the microbiota of a patient with alcoholic hepatitis. Quantification of mRNA levels of glucose transporters (glucose transporter 2 and 5, Glut2, Glut5; Sodium/glucose cotransporter 1, SGLT1) (A) and lipid transporters (cluster of differentiation 36, CD36; fatty acid binding protein 1, Fabp1; fatty acid transporter 4, Fatp4; small heterodimer partner, SHP) (D) by qPCR. Principal component analysis of fecal glucose-metabolites (B) and fecal lipid metabolites (E). Carbohydrates (C) and lipid (F) metabolite quantification in feces. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.