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Overview of the components of the tumor microenvironment (TME). The cellular composition of the TME is quite heterogeneous and consists of various cell types. These include (i) tumor cells (upper right) as well as (ii) stromal cells (lower left) and (iii) immune cells (lower right). Soluble factors secreted by the cells of the TME (red stars) also play an important role, as do structural components, such as (iv) the extracellular matrix (ECM; upper left).
