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Cytotoxic and non-cytotoxic tumor immune control. The cartoon summarizes the control of a tumor by non-toxic mechanisms executed by CD4+ T cells that secrete pro-inflammatory cytokines (upper part of the cartoon) or toxic mechanisms executed by tumor-infiltrating cytotoxic CD8+ T cells (lower part of the cartoon). Abbreviations: SASP, senescence-associated secretory phenotype; TME, tumor microenvironment.
