Table 2.
Multivariable analysis of 5-year recurrence free survival in patients with pancreatic neuroendocrine tumor.
| Variable | Univariable HR (95% CI) | p | Multivariable HR (95% CI) | p |
|---|---|---|---|---|
| Age (per year) | 0.99 (0.97–1.01) | 0.33 | - | - |
| Male sex | 0.95 (0.47–1.90) | 0.88 | - | - |
| LVI absent | Referent | - | - | - |
| LVI present | 5.19 (2.18–12.34) | <0.001 * | - | - |
| T1/T2 | Referent | - | Referent | - |
| T3/T4 | 6.42 (2.82–14.58) | <0.001 | 2.78 (1.07–7.23) | 0.04 |
| Node positive | 3.37 (1.68–6.77) | 0.001 * | - | - |
| Grade 3 | Referent | - | Referent | - |
| Grade 2 | 0.17 (0.07–0.43) | <0.001 | 0.20 (0.07–0.54) | 0.002 |
| Grade 1 | 0.04 (0.01–0.10) | <0.001 | 0.07 (0.02–0.22) | <0.001 |
| R1 margin | 3.33 (1.44–7.71) | 0.005 | 2.43 (0.96–6.15) | 0.06 |
| Minimally invasive approach | 0.58 (0.28–1.19) | 0.14 * | - | - |
* Removed from final model following single backward elimination. Abbreviations: HR = hazard ratio; CI = confidence interval; LVI = lymphovascular invasion.