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. 2022 Mar 18;14(6):1555. doi: 10.3390/cancers14061555

Figure 3.

Figure 3

The key downstream target molecules and function pathways of mTORC1. mTORC1 is a master regulator of cellular anabolism and promotes cell metabolism, growth, and proliferation by regulating a variety of downstream effectors, including mRNA translation; biosynthesis of proteins, nucleotides, and lipids; autophagy; lysosomal biogenesis; and angiogenesis. 4E-BP, 4E-binding protein; eIF-4E, eukaryotic translation initiation factor 4E; S6K1, p70 S6 kinase 1; eIF-A/B, eukaryotic translation initiation factor 4A/B; HIF1α, hypoxia-inducible factor 1α; PGC1α, peroxisome proliferator-activated receptor γ coactivator 1-α; SREBP, sterol regulatory element-binding protein; PPARγ peroxisome proliferator-activated receptor-γ; TFEB, transcription factor EB; TFE3, transcription factor E3; ULK1, unc-51-like autophagy- activating kinase 1; ATG13, autophagy-related 13; AFT4, activating transcription factor 4.