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The key downstream target molecules and function pathways of mTORC2. mTORC2 activates the AGC (protein kinase A/protein kinase G/protein kinase C) family kinases PKC, AKT, and SGK to regulate the cytoskeleton, metabolism, and ion transport and promote cell survival. PKC, protein kinase C; SGK, serum- and glucocorticoid-induced protein kinase; GSK3β, glycogen synthase kinase 3β; TSC2, tuberous sclerosis complex 2.
