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. 2022 Mar 9;12(3):422. doi: 10.3390/biom12030422

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Summary diagram. (A)SIRT1 knockdown (SIRT1^+/−) mice showed typical pre-eclampsia-like symptoms, such as hypertension, kidney injury, FGR, and placental pathology. These performances could be improved after intraperitoneal injection of SIRT1 agonist SRT2104 and P4. Metformin could also reduce the elevated blood pressure, but caused FGR. (B) Additionally, P4 could promote the invasion and inhibit the apoptosis of trophoblasts. (PE: pre-eclampsia; FGR: fetal growth restriction; P4: progesterone; Met: metformin.).