FIG. 2.

Mean (SEM) PMN recruitment in alveolar spaces (A), lung homogenate (B), and blood (C), as evaluated by cell count (A and C) and MPO assay (B). Infection was induced at time zero with 3.5 × 10⁷ CFU of S. pneumoniae/mouse, and treatment with L-NMMA (3 mg/kg doses) was started at time zero and maintained twice daily throughout the experiment. ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001; all compared to preinfection values. §, P < 0.01; ¶, P < 0.001; both between infected and infected plus L-NMMA-treated mice.