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. 2022 Mar 14;12(3):445. doi: 10.3390/biom12030445

Figure 2.

Figure 2

The circulating level of sTIM-3 is increased in COVID-19 patients, mainly in those that required IMV. Serum levels of sTIM-3 were evaluated in total COVID-19 patients and divided into invasive mechanic ventilation (IMV) and non-invasive mechanic ventilation (NIMV) groups (a,b). Serum levels of sGal-9 were evaluated in total COVID-19 patients and divided into IMV and NIMV groups (c,d). Graphs show individual values and the mean ± SD. Statistical analysis was performed with the Mann–Whitney test (a,c) or an ANOVA test adjusted by the Kruskal–Wallis method (b,d). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Asterisks indicate a significant comparison with the healthy donor (HD) group, and when the asterisk is over a line, it indicates a significant comparison between IMV and NIMV. Empty circles represent healthy donors group, empty triangles COVID-19 group, black circles IMV group, empty diamonds NIMV group.