Table 1.

Summary for the AKT-regulating–AKT-signaling network and modulating migration and angiogenesis.

Drugs/Proteins	Activation	Inactivation	Migration Effects	Cells	References
Section 8.1. The Network between AKT, MMP-2/9, EMT, and Migration
ARP100, AG-L-66085		MMP-2/9	inhibit	retinoblastoma	[56]
Tanshinone IIA		AKT, MMP-9	inhibit	aortic smooth muscle	[57]
siRNA eEF1A2		AKT, MMP-9	inhibit	pancreatic cancer	[47]
Paeonol		EMT	inhibit	pancreas cancer	[58]
Emodin		EMT	inhibit	colon cancer	[59]
Section 8.2. AKT Regulates Several Migration- and Angiogenesis-Related Genes to Modulate EMT
MAPK	AKT			fibroblast, cancer	[60,61]
POMx		MMP-2/9, EMT	inhibit	oral cancer	[62]
PDGF	AKT		promote	aortic smooth muscle	[63]
High glucose	AKT, VEGF-C			prostate cancer	[64]
AKT	eNOS			endothelial cells	[65]
EGF	AKT		promote	oral cancer	[66]
EGFR	EMT			breast cancer	[67]
AKT	FOXO1			prostate cancer	[68]
circSTK40	HSP90, AKT			breast cancer	[69]
HSP90	EMT		promote	colorectal cancer	[70]
Section 8.3. AKT Network, Warburg Effect, Migration, and Angiogenesis
PDK1	Warburg effect		promote	lung cancer	[71]
High glycolysis	Warburg effect		angiogenesis	endothelial	[72]
MCT1	Warburg effect		angiogenesis	endothelial	[73]
AKT	Warburg effect			cancer	[74]
p38γ MAPK	Warburg effect			pancreatic cancer	[75]
PDGF, AKT	Warburg effect			aortic smooth muscle	[63]
F1,6BP, EGFR	Warburg effect			breast cancer	[76]
NOS, HK2	Warburg effect			ovarian cancer	[77]
FOXO3a		Warburg effect		glioblastoma	[78]
HIF-1α, VEGF	Warburg effect			lung cancer	[79]
HSP90, PKM2	Warburg effect			liver cancer	[80]