Table 1.

Sex differences in neurologic conditions, Comparative data between AD and PD and other diseases described in the text are briefly reported. Note that the incidence, some clinical aspects and the outcome show sex-related differences. Treatments also display some sex disparity.

Sex and Neurologic Disease
	Incidence	Clinical Aspects	Outcome	Therapy
Alzheimer’s disease	F > M -Ages 65–69: 0.7% vs. 0.6% [24] -Ages 86–89: 14.2% vs. 8.8% [24]	-Depression and anxiety: F > M [26] -Agitation and hostile behavior: M > F [26]	-Dementia: F > M [25,26] -Cognitive deterioration: F > M [25,26]	Early hormonal therapy: protective for females [34]
Parkinson’s disease	M > F -Male-to-female ratio 1.6:1 [37]	-Hypersalivation, sexual dysfunction and excessive daytime sleepiness: quicker onset in M [37] -Neuropsychiatric and motor symptoms: worse in M [37] -Difficulty in daily living activities: F > M [37] -Fatigue, depression and tremor: F > M [37]	-Dementia: M > F [37] -Death: M > F [37]	Mean time interval between initiation of treatment with levodopa and onset of levodopa-induced dyskinesia: F > M (6 y vs. 4 y) [41,42]
Epilepsy	M > F: 50.7/100,000 vs. 46.2/100,000 [44] Subtypes [45,46]: -Symptomatic partial type seizures: M > F -IGE: F > M -JME: F > M -TLE: F > M -Idiopathic generalized tonic-clonic seizure: F > M			Affiliation of valproate with endocrine disorders in female (such as amenorrhea, polycystic ovaries and decreased libido) [49,50]
Depression	F > M [52]			Women in post menopause might benefit from a combination therapy with hormones [57]