Table 2.
Putative drug targets significantly altered in the VTE vs. control groups *.
| Symbol | VTE vs. Control (Protein, log1.5FC) |
Protein Name | Location | Drug(s) |
|---|---|---|---|---|
| PDGFB | 3.089 | platelet derived growth factor subunit B | Extracellular Space | sunitinib |
| COL3A1 | 2.428 | collagen type III alpha 1 chain | Extracellular Space | collagenase clostridium histolyticum |
| COL1A1 | 2.236 | collagen type I alpha 1 chain | Extracellular Space | collagenase clostridium histolyticum |
| COL1A2 | 2.007 | collagen type I alpha 2 chain | Extracellular Space | collagenase clostridium histolyticum |
| CXCL12 | 1.805 | C-X-C motif chemokine ligand 12 | Extracellular Space | NOX-A12 |
| APCS | 1.772 | amyloid P component, serum | Extracellular Space | dezamizumab |
| COL16A1 | 1.719 | collagen type XVI alpha 1 chain | Extracellular Space | collagenase clostridium histolyticum |
| TNFSF13 | 1.703 | TNF superfamily member 13 | Extracellular Space | BION-1301 |
| COL8A1 | 1.658 | collagen type VIII alpha 1 chain | Extracellular Space | collagenase clostridium histolyticum |
| COL5A2 | 1.522 | collagen type V alpha 2 chain | Extracellular Space | collagenase clostridium histolyticum |
| COL14A1 | 1.521 | collagen type XIV alpha 1 chain | Extracellular Space | collagenase clostridium histolyticum |
| MMP28 | 1.481 | matrix metallopeptidase 28 | Extracellular Space | marimastat |
| TTR | 1.233 | transthyretin | Extracellular Space | tafamidis |
| APOC3 | 1.166 | apolipoprotein C3 | Extracellular Space | volanesorsen |
| COL6A1 | 1.154 | collagen type VI alpha 1 chain | Extracellular Space | collagenase clostridium histolyticum |
| AOC3 | 1.152 | amine oxidase copper containing 3 | Plasma Membrane | ASP8232 |
| DPP4 | 0.919 | dipeptidyl peptidase 4 | Plasma Membrane | saxagliptin |
| APOA1 | 0.903 | apolipoprotein A1 | Extracellular Space | ISIS 681257 |
| PDGFRB | 0.875 | platelet derived growth factor receptor beta | Plasma Membrane | midostaurin |
| COL6A3 | 0.803 | collagen type VI alpha 3 chain | Extracellular Space | collagenase clostridium histolyticum |
| BST1 | 0.803 | bone marrow stromal cell antigen 1 | Plasma Membrane | MEN1112 |
| COL6A2 | 0.791 | collagen type VI alpha 2 chain | Extracellular Space | collagenase clostridium histolyticum |
| ABCB1 | 0.609 | ATP binding cassette subfamily B member 1 | Plasma Membrane | dofequidar |
| PTGS1 | −0.876 | prostaglandin-endoperoxide synthase 1 | Cytoplasm | sulindac/tamoxifen |
* LIMMA p < 0.01, ±1.5-fold change.