Cousson 2005.

Methods	Single‐centre, prospective, randomised trial.
Participants	16 intensive care patients (median age 61 years; 75% male) with severe nosocomial gram‐negative pneumonia requiring mechanical ventilation. Exclusion: weight > 100 kg, pregnant or breastfeeding, beta‐lactam allergy, creatinine clearance < 60 mL/min, pulmonary fibrosis.
Interventions	Ceftazidime 20 mg/kg i.v. loading dose, then 60 mg/kg i.v. continuous infusion vs ceftazidime 20 mg/kg i.v. over 30 minutes q8h; treatment duration not stated.
Outcomes	Pharmacodynamic profile of ceftazidime (duration plasma concentration > 20 mg/L).
Notes	Pharmacokinetic study, no clinical outcomes. Article in French translated into English.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomly assigned using a random numbers table (pg. 547).
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not stated.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All randomly assigned participants were accounted for at end of study.
Selective reporting (reporting bias)	Low risk	Reported on all pre‐specified outcomes of interest.
Other bias	Unclear risk	Tobramycin use permitted in both groups (pg. 548).